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Moacir Wajner Selected Research

Oxidoreductases (Dehydrogenase)

11/2023In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury.
4/2023L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress.
1/2022Pathophysiology of maple syrup urine disease: Focus on the neurotoxic role of the accumulated branched-chain amino acids and branched-chain α-keto acids.
10/2016Disturbance of mitochondrial functions provoked by the major long-chain 3-hydroxylated fatty acids accumulating in MTP and LCHAD deficiencies in skeletal muscle.
10/2015Investigation of inflammatory profile in MSUD patients: benefit of L-carnitine supplementation.
6/2015Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency.
5/2015L-Carnitine supplementation decreases DNA damage in treated MSUD patients.
3/2014Neurological damage in MSUD: the role of oxidative stress.
5/2008Evidence that 3-hydroxyisobutyric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats.
10/2003Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease.

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Moacir Wajner Research Topics

Disease

35Maple Syrup Urine Disease
11/2023 - 03/2002
30Glutaric Acidemia I
01/2022 - 05/2002
22Body Weight (Weight, Body)
06/2018 - 05/2002
16Phenylketonurias (Phenylketonuria)
11/2023 - 04/2002
16Metabolic Diseases (Metabolic Disease)
06/2023 - 09/2002
142-Hydroxyglutaricaciduria
04/2023 - 01/2002
14Homocystinuria
11/2017 - 04/2002
13Mitochondrial Diseases (Mitochondrial Disease)
05/2023 - 12/2008
12Neurodegenerative Diseases (Neurodegenerative Disease)
04/2014 - 12/2005
11Inborn Genetic Diseases (Disease, Hereditary)
12/2023 - 08/2006
11Propionic Acidemia
08/2022 - 10/2002
11Medium chain acyl CoA dehydrogenase deficiency
01/2020 - 08/2003
9Ethylmalonic encephalopathy
12/2023 - 02/2009
9Peroxisomal Disorders (Peroxisomal Disorder)
01/2023 - 09/2006
9Brain Diseases (Brain Disorder)
12/2022 - 12/2004
9Atrophy
01/2021 - 05/2002
9Intellectual Disability (Idiocy)
12/2012 - 04/2002
8Methylmalonic acidemia
11/2022 - 06/2003
8Brain Injuries (Brain Injury)
01/2022 - 12/2005
7Seizures (Absence Seizure)
12/2022 - 08/2007
7Cystinosis
05/2008 - 06/2004
6Gliosis
11/2023 - 12/2008
6Nonketotic Hyperglycinemia
08/2023 - 08/2011
6Demyelinating Diseases (Demyelinating Disease)
04/2023 - 11/2007
6Refsum Disease (Refsum's Disease)
01/2023 - 08/2010
6Neurologic Manifestations (Neurological Manifestations)
12/2020 - 06/2003
6Glioma (Gliomas)
03/2014 - 02/2006
6Guanidinoacetate methyltransferase deficiency
09/2008 - 06/2003
5Huntington Disease (Huntington's Disease)
05/2023 - 09/2004
5Cardiomyopathies (Cardiomyopathy)
04/2023 - 07/2012
5Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked)
05/2016 - 09/2006
5Short chain Acyl CoA dehydrogenase deficiency
08/2014 - 12/2002
5Hyperargininemia
03/2007 - 07/2002
4Inborn Errors Metabolism (Inborn Errors of Metabolism)
01/2023 - 05/2015
4Inflammation (Inflammations)
11/2022 - 12/2015
4Ataxia (Dyssynergia)
06/2022 - 02/2013
4Hypermethioninemia
04/2019 - 11/2005
4Familial Hypertryptophanemia
06/2008 - 06/2003

Drug/Important Bio-Agent (IBA)

54AcidsIBA
11/2023 - 01/2002
30AntioxidantsIBA
06/2023 - 03/2002
29EnzymesIBA
03/2024 - 06/2002
22Glutaryl-CoA DehydrogenaseIBA
08/2022 - 06/2007
20Fatty Acids (Saturated Fatty Acids)IBA
02/2020 - 12/2004
20Adenosine Triphosphatases (ATPase)IBA
07/2018 - 04/2002
19Amino AcidsFDA Link
12/2023 - 05/2003
19Keto AcidsIBA
11/2023 - 03/2003
16Phenylalanine (L-Phenylalanine)FDA Link
11/2023 - 04/2002
15Proteins (Proteins, Gene)FDA Link
08/2023 - 12/2002
12Carnitine (L-Carnitine)FDA LinkGeneric
06/2023 - 03/2009
12Branched-Chain Amino AcidsIBA
01/2022 - 03/2003
12Tryptophan (L-Tryptophan)FDA Link
01/2022 - 06/2003
12glutaric acidIBA
01/2021 - 02/2003
12HomocysteineIBA
11/2017 - 06/2002
10Oxidoreductases (Dehydrogenase)IBA
11/2023 - 10/2003
10Lysine (L-Lysine)FDA Link
01/2022 - 06/2009
9Glycine (Aminoacetic Acid)FDA LinkGeneric
08/2023 - 11/2009
8ethylmalonic acid (ethylmalonate)IBA
01/2021 - 05/2003
8Creatine Kinase (Creatine Phosphokinase)IBA
02/2013 - 04/2003
8Cystine (L-Cystine)IBA
05/2008 - 06/2004
7Leucine (L-Leucine)FDA Link
11/2023 - 03/2003
7Glutathione (Reduced Glutathione)IBA
11/2022 - 06/2004
7CreatineIBA
01/2017 - 06/2004
7Thiobarbituric Acid Reactive SubstancesIBA
06/2010 - 06/2003
6Phytanic AcidIBA
01/2023 - 08/2010
6Quinolinic AcidIBA
01/2022 - 12/2005
6KynurenineIBA
01/2022 - 06/2003
6Glutamic Acid (Glutamate)FDA Link
04/2014 - 06/2002
6Glutathione PeroxidaseIBA
12/2012 - 06/2003
6CatalaseIBA
12/2012 - 06/2003
6glycocyamineIBA
09/2008 - 06/2003
6Sulfhydryl Compounds (Thiols)IBA
09/2008 - 06/2004
6Cysteamine (Mercaptamine)FDA Link
05/2008 - 06/2004
6alpha-ketoisocaproic acidIBA
09/2007 - 12/2002
5BezafibrateIBA
05/2023 - 01/2017
5Methylmalonic AcidIBA
11/2022 - 06/2003
5Proline (L-Proline)FDA Link
05/2018 - 04/2003
5Methionine (L-Methionine)FDA Link
11/2017 - 06/2002
5Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA
01/2016 - 08/2003
5ButyrylcholinesteraseIBA
08/2015 - 09/2003
5Folic Acid (Vitamin M)FDA LinkGeneric
08/2015 - 02/2006
5HHH syndromeIBA
08/2015 - 11/2009
5Arginine (L-Arginine)FDA Link
03/2007 - 07/2002
4Tyrosine (L-Tyrosine)FDA Link
11/2023 - 10/2008
4Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA
11/2023 - 05/2002
4SulfitesIBA
08/2023 - 12/2013
4AmmoniaIBA
12/2022 - 03/2006
4LipidsIBA
01/2019 - 07/2009
4Alanine (L-Alanine)FDA Link
06/2018 - 09/2002
4Isoleucine (L-Isoleucine)FDA Link
10/2015 - 05/2007
4Valine (L-Valine)FDA Link
10/2015 - 05/2007
4Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
08/2015 - 06/2009
4Butyryl-CoA Dehydrogenase (Short-Chain Acyl-CoA Dehydrogenase)IBA
02/2010 - 05/2003
4Glucose (Dextrose)FDA LinkGeneric
06/2009 - 03/2003
4Guanidinoacetate N-Methyltransferase (Guanidinoacetate Methyltransferase)IBA
09/2008 - 06/2003
43-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) (Alpha-Keto Acid Dehydrogenase)IBA
03/2008 - 06/2005
3Hydrogen Sulfide (Sulfide, Hydrogen)IBA
12/2023 - 01/2017
3ThiosulfatesIBA
12/2023 - 12/2013
3Sulfite OxidaseIBA
08/2023 - 11/2016

Therapy/Procedure

11Therapeutics
06/2023 - 03/2002
9Subcutaneous Injections
12/2012 - 04/2003